Macedonian Journal of Medical Sciences
نویسندگان
چکیده
Prodynorphin (PDYN; OMIM: 131340) is the precursor of the dynorphin related peptides which plays an important role in several complex traits such as drug abuse [1]. It has been reported that the expression level of the PDYN gene is significantly increased by cocaine [2]. On the other hand, the Pdyn knockout mice showed increased explorative behavior in anxiety tests suggesting an anxiogenic role of peptides derived from PDYN [3]. The PDYN family of neuropeptides comprises six peptides of varying lengths that are formed from the precursor PDYN and which activate kappa-opioid receptors (KORs) located in the peripheral and central nervous systems. The functional genetic polymorphisms in the PDYN gene may affect the level of transcription, or response to environmental or internal stimuli. This would in turn result in downstream neurobiological and behavioral adaptations (e.g., proximally through dynorphins’ agonist actions on KORs). Therefore, genetic variations or epigenetic changes of the PDYN could underlie vulnerability to drug dependence [4, 5].
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1. Dept. of Epidemiology, School of Public Health, Shahid Beheshti University of Medical Sciences, Tehran, Iran 2. Dept. of Epidemiology and Biostatistics, School of Public Health, Tehran University of Medical Sciences, Tehran, Iran 3. Social Determinants of Health Research Center, Kurdistan University of Medical Sciences, Sanandaj, Iran 4. Department of Epidemiology, School of Public Health, I...
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1 Biochemistry Department, Faculty of Basic Medical Sciences, Ladoke Akintola University of Technology, Ogbomoso, Nigeria; 2 Biochemistry Department, College of Medicine, University of Ibadan, Ibadan, Nigeria; 3 Anatomy Department, Faculty of Basic Medical Sciences, Ladoke Akintola University of Technology Ogbomoso, Ogbomoso, Nigeria; 4 Veterinary Microbiology and Parasitology Department, Facul...
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